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Contrave is really a combination from the drugs naltrexone and bupropion, which usually reflect a whole new trend of weight-loss drugs that are made up of many active ingredient, which might make them more efficient and safer. Combo-pilling is the newest fad or better yet the newest in the future under scrutiny and therefore it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular could be the fact that as of right now there are no long term prescription slimming capsules that have been licensed by the FDA apart from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be authorized by the FDA. Seizures can be a side effect with Contrave and really should not be taken in individuals with seizure disorders. 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