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Using two separate drugs to shed weight can be very effective you will find combinations in front of the FDA now awaiting approval. When dealing with weight loss and the people who go through it you should err along the side of caution and allow FDA do its job and demand some study be done in order that the public is aware of the side effects and dangers of the medications before we bring them. Keep in mind that drug companies have been in business to earn money and that they would say everything to keep people on their own medications. Researchers found that participants taking this drug for a year, lost weight within one month and have kept the load off through the entire 56 weeks in the study. Contrave can be a combination from the drugs naltrexone and bupropion, which generally seems to reflect a whole new trend of weight-loss drugs which might be made up of several active ingredient, that might make them more efficient and safer. Combo-pilling may be the newest fad or better yet the newest to come under scrutiny and so it is just more publicly known in recent months, comb-pilling for weight loss has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular could be the fact that as of right now there are no long term prescription slimming capsules that have been approved by the FDA apart from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications however some of the combinations have been rejected or have yet to be approved by the FDA. Seizures certainly are a side effect with Contrave and mustn't be taken in those with seizure disorders. The drug also can raise blood pressure and pulse rate, and really should not be used in people with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure and heartbeat and must not be used in patients with uncontrolled high blood pressure levels, along with by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting the mind) disease. Patients using a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients on the increased risk of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stop smoking. "This may be the first drug I'm conscious of that targets both appetite and reward centres within the brain," he said.