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Combo-pilling may be the newest fad or even better the newest in the future under scrutiny and for that reason it is just more publicly known although in the past, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular will be the fact that at the time of right now there aren't long term prescription diet pills that have been authorized by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be approved by the FDA. Seizures certainly are a side effect with Contrave and mustn't be taken in people with seizure disorders. The drug may also raise blood pressure levels and heartbeat, and really should not be used in people with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure level and heart rate and must stop used in patients with uncontrolled high blood pressure level, along with by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients using a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients on the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking. 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